Abstract
Two β-adrenergic blocking agents, 1-[(1-methylethyl)amino]-3-phenoxy-2-propanol (1) and 1-[(1-methylethyl)amino]-3-(3-methylphenoxy)-2-propanol (2; Toliprolol), were enantioseparated by pH-zone-refining countercurrent chromatography. A two-phase solvent system composed of chloroform containing 0.10mol/L of di-n-hexyl l-tartrate/0.10mol/L of boric acid aqueous solution (1:1, v/v) was selected, in which 20mmol/L triethylamine was added in the organic phase as a retainer and 2mmol/L HCl was added in the aqueous phase as an eluter. Fifty milligrams of each racemate was completely enantioseparated by pH-zone-refining countercurrent chromatography to yield each enantiomer with a purity of more than 98%, and the recovery of each separated enantiomer reached around 76-82%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
