Abstract
Glenn's method of orthogonal functions ( J. Pharm. Pharmacol., 15 (1963) 123T–130T) is extended to the spectrophotometric determination of dissociation constants of some weakly acidic and basic drugs. The calculated comparative coefficients, Q j , of the dissociated, undissociated and partially dissociated forms of the drug have been used to calculate the pK a values. A graphical technique based upon plotting orthogonal function titration curves is also presented. The results obtained are in good agreement with the reported values.
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