Application of oral food challenge in the diagnosis of gastrointestinal food allergy in the children

Abstract

Food allergy is a common illness in children, which is divided into IgE-mediated, non-IgE mediated and mixed-mediated food allergy.Gastrointestinal tract is the mainly affected organ, mostly mediated by non-IgE mechanism.Gastrointestinal food allergy are lack of unified diagnostic criteria currently, whose mechanism is also elusive.Moreover, the double-blind placebo-controlled food challenge is the gold standard for the diagnosis of food allergy.This review focuses on the procedure for the oral food challenge and its application in the diagnosis of gastrointestinal food allergy. Key words: Oral food challenge; Food allergy; Gastrointestinal tract; Diagnosis