Abstract
Possible early diagnostic application of optical methods (dielectrophoresis, spectral and imaging ellipsometry, Fourier-transform infrared spectroscopy, Raman spectroscopy) in studies of red blood cells and serum of patients with diffuse liver disease with varying degrees of fibrosis has been evaluated. Application of combined optical methods was confirmed to significantly improve the performance of sensitivity, specificity, and accuracy index as well as to achieve the reliable results in diagnosis of both severe fibrosis and slight ulterior liver fibrosis. Identified diagnostic potential of optical methods can be effectively utilized in noninvasive screening evaluation of stages of diffuse liver disease of various geneses.
Highlights
Evaluation of the stage of the disease and the severity rate of liver fibrosis remains to be one of the key issues in verification of the diagnosis in patients with diffuse liver pathology as this evaluation predetermines prognosis and administration of adequate therapy
Total 62 males aged 38 - 69 with diffuse liver pathology who gave their written consent for involvement in the clinical trials were included into the study
The severity rate of fibrosis was confirmed by liver biopsy performed in 21 patients with diffuse liver diseases
Summary
Evaluation of the stage of the disease and the severity rate of liver fibrosis remains to be one of the key issues in verification of the diagnosis in patients with diffuse liver pathology as this evaluation predetermines prognosis and administration of adequate therapy. The issue of diagnosis of early stages of the liver fibrosis remains to be critical as they are known to be reversible [1]. Numerous methods of determining stages of liver fibrosis have been proposed, i.e. biochemical, macro-morphological, semiquantitative ones etc. Liver biopsy remains to be the “gold standard” in resolution of this issue. Even liver biopsy raises some issues of a subjective nature of the results obtained, the necessity to study several biopsy materials and frequent objections on the part of patients under study
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