Application of ofloxacin in gynaecology.

Abstract

Most infections in obstetrics and gynaecology are ascendant infections from the vaginal area or from the lower urinary tract. Apart from specific pathogens, like gonococci and Chlamydia trachomatis, many different bacteria may be involved and can often be detected in high concentrations, by the use of suitable methods, especially in soft tissue infections. The risk of infection is dependent on the concentration of facultative pathogenic bacteria (Petersen et al. 1986), synergisms between different bacteria, surgical action, and the condition of the immune system (Ledger 1986). In severe infections, broad spectrum antibiotics and combinations are preferred. In moderate infections, single-drug therapy is preferred. Preserving the normal lactobacilli flora may be an important factor in choosing between different antimicrobials with similar spectra. In more than 70% of all women, high concentrations of lactobacilli alone are found , and it is well known 183