Abstract
Polymers containing nanoparticles dispersed and distributed in the matrix can be used for control of drug release. In this work, hydrophilic matrix systems were prepared using poly(vinyl alcohol) and unmodified clay containing the same amount of cephalexin. The materials were obtained through in situ polymerization and were characterized by the conventional technique of FTIR and NMR relaxometry, through determination of proton spin-lattice relaxation time, in order to understand the molecular behavior of the new materials. The NMR relaxometry data showed that the new materials containing low quantities of clay (0.25% and 0.75%) and the same amount of cephalexin (0.5 g) had very good dispersion and distribution of the clay and drug in the polymer matrix. The combination of clay and cephalexin formed a more homogenous material with a narrow domain curve and low relaxation values. The material containing 0.25% clay presented a mixed morphology, with part exfoliated and part intercalated, as could be seen from the relaxation domain distribution, which was larger than that for material with 0.75% clay.
Highlights
IntroductionHow to cite this paper: de Pádua Castelo Branco Cunha, A., Tavares, M.I.B. and da Silva, E.O. (2016) Application of nuclear magnetic resonance (NMR) Relaxometry to Study Nanostructured Poly(vinyl alcohol)/MMT/ Cephalexin Materials for Use in Drug Delivery Systems
The generation of nanostructured systems for application in the pharmaceutical industry has been a subject ofHow to cite this paper: de Pádua Castelo Branco Cunha, A., Tavares, M.I.B. and da Silva, E.O. (2016) Application of nuclear magnetic resonance (NMR) Relaxometry to Study Nanostructured Poly(vinyl alcohol)/MMT/ Cephalexin Materials for Use in Drug Delivery Systems
FTIR spectrum of the system formed by poly(vinyl alcohol) (PVAL)/Clay/cephalexin containing 1.0% clay and 0.5 g of cephalexin. bands corresponding to axial deformation of OH located in the range of 3550 - 3200 cm−1 indicates the presence of hydrogen bonding, while the absence of strong absorption in the 3650 - 3584 cm−1 range is characteristic of free OH indicates a high concentration of intermolecular linked hydroxyl
Summary
How to cite this paper: de Pádua Castelo Branco Cunha, A., Tavares, M.I.B. and da Silva, E.O. (2016) Application of NMR Relaxometry to Study Nanostructured Poly(vinyl alcohol)/MMT/ Cephalexin Materials for Use in Drug Delivery Systems. (2016) Application of NMR Relaxometry to Study Nanostructured Poly(vinyl alcohol)/MMT/ Cephalexin Materials for Use in Drug Delivery Systems. The predominance of one of these mechanisms invariably depends on the properties of the polymer used in the system, among which poly(vinyl alcohol) (PVAL) stands out. In this work we prepared a hydrophilic nanostructured system using poly(vinyl alcohol), because this polymer had very good characteristics for use as a hydrophilic matrix for delivery of hydrophilic drugs like cephalexin. It is resistant to oil, grease and solvents It has high tensile strength and flexibility, as well as high oxygen and aroma barrier properties. The main objective of this work was to prepare hydrophilic matrix systems using poly(vinyl alcohol) and unmodified clay and cephalexin. The contrary effect in proton relaxation time is expected for the samples containing polymer chains intercalated in the clay lamellae because of the restriction of their molecular mobility [7]-[12]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
