Abstract
The authors of the recently published review, "Why the Gold Standard Approach by Mammography Demands Extension by Multiomics [...].
Highlights
The authors of the recently published review, “Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management”, elegantly describe miRNAs as potential blood-based biomarkers for early breast cancer detection [1]. They fail to mention the potential of nipple aspirate fluid (NAF) as a source of miRNAs
NAF collection causes significantly less discomfort compared to other breast cancer screening modalities [3,4], and we and others have shown the feasibility of measuring miRNAs in NAF, pathological nipple discharge, and breast ductal fluids [7,8,9,10]
We have demonstrated that using the same technique and thresholds, but more sample volume input (200 μL serum instead of 20 μL NAF), merely 144/754 (19%) profiled miRNAs could be detected in serum from healthy women, as opposed to 240/754 miRNAs (32%) in NAF [9]
Summary
Application of Nipple Aspirate Fluid miRNA Profiles for Early Breast Cancer Detection and Management Department of Pathology, University Medical Center Utrecht—Utrecht University, 3508 GA Utrecht, The Netherlands; S.I.SchoutenPatuleia-7@umcutrecht.nl (S.I.S.P.); P.J.vanDiest@umcutrecht.nl (P.J.D.) Department of Epidemiology of the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht—Utrecht University, 3508 GA Utrecht, The Netherlands; C.vanGils@umcutrecht.nl
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