Abstract
AbstractThe problem of developing an approach for modelling the response of an organism to chronic toxicity is discussed in this paper and illustrated by studying the toxic effect of NaBr on the reproduction process of a population of Daphnia magna. A general model is given which includes both the negative binomial and poisson distributions as special cases depending on the values of a single parameter. The steps involved in estimating the parameters of the model and testing the goodness‐of‐fit are presented. In particular the iterative solution of the estimating equations are described in detail along with the problem of setting confidence limits for model parameters. This approach is useful in the analysis of quantal bioassay data.
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