Abstract
According to the latest requirements of World Health Organization and U.S.Food and Drug Administration for detecting mycobacteria in biological products,mycobacteria detection is first added to quality control of live attenuated Japanese encephalitis vaccine.This article reviews classification and characteristics of mycobacteria,pathogenicity of different kinds of mycobacteria and common technology for detecting mycobacteria,and introduces different methods for detecting mycobacteria in quality control of Japanese encephalitis vaccine.Nucleic acid amplification assay for detecting mycobacteria is first applied to quality control of biological products in our country. Key words: Mycobacterium ; Biological products ; Quality control ; Japanese encephalitis vaccines ;
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