Application of Molecular Profiling in Colorectal Cancer Surgery.

Abstract

Although molecular profiling has long been integrated into the systemic therapy of metastatic colorectal cancer, it did not arouse enough attention in colorectal cancer surgery until Cercek's study showing that microsatellite instability-high (MSI-H) rectal cancer might be cured by anti-PD-1 therapy. With the advance of precision medicine, we are getting closer to understand the nature of colorectal cancer, the relationship between molecular profiling and phenotype, and its impact on surgical management of colorectal cancer.