Abstract
Triterpenoids and phytosteroids from stem bark of Crataeva nurvala buch ham.Shumaia Parvin, Md. Abdul Kader, Md. Abdul Muhit, Md. Ekramul Haque, Md. Ashik Mosaddik, Mir Imam Ibne Wahed
Highlights
Symplocos racemosa Roxb. (Symplocaceae), is an evergreen tree found in the plains and lower hills throughout India (Jadhav et al, 2013)
The present study aims to develop and validate an efficient RP-HPLC method for the quantification of betulinic acid from the bark of Symplocos racemosa and an Ayurvedic formulation
Estimation of betulinic acid from the bark extract of S. racemosa collected from Mahabaleshwar in two different seasons
Summary
Symplocos racemosa Roxb. (Symplocaceae), is an evergreen tree found in the plains and lower hills throughout India (Jadhav et al, 2013). The bark of S. racemosa is traditionally used in treatment of liver and bowel complaints, tumors, uterine disorders, asthma, fever, snake-bite, gonorrhea and arthritis, gynaecological disorders, menorrhagia, leucorrhea & other menstrual disorders. Bark of S. racemosa is reported for anti-cancer, hepatoprotective, antioxidant, anti-androgenic, anti-inflammatory, wound healing, anti-microbial and anti-diabetic activity (Acharya et al, 2016; Menghani et al, 2011). The therapeutic use of the plant is principally attributed to the presence of biomarkers (Shailajan et al, 2015) of which betulinic acid, pentacyclic triterpenoid (Figure 1), is one of the bioactive phytoconstituents betulinic acid has a wide range of biological and medicinal properties, including anti-human immunodeficiency virus (HIV), antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinociceptive, anti-herpes simplex viruses-1 (HSV-1), immunemodulatory, antiangiogenic, and anticancer activity (Sook et al, 2015).
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