Application of Modern Green Chemistry Methods in the Synthesis of Quinolines, Quinazolines and Quinazolinones

Abstract

<div>In the last few decades, there is a constant demand for novel bioactive</div><div>compounds in all areas of pharmacy and medicine, thus increasing the demands for</div><div>their design and synthesis. Quinolines, quinazolines and quinazolinones, highly</div><div>bioactive heterocyclic compounds with a nitrogen core, have been employed in many</div><div>important drugs nowadays. Their synthesis often includes an enormous amounts of</div><div>different hazardous organic solvents, catalysts, as well as energy consumption. In the</div><div>last two decades, there is a growing interest in the application of different green</div><div>chemistry methods in different research areas, including synthesis. This chapter</div><div>describes their application in the synthesis of the above mentioned compounds.</div><div>Microwave-assisted, ultrasound-assisted, mechanochemical synthesis in the</div><div>combination with solvent-free synthesis and synthesis in deep eutectic solvents (DESs)</div><div>and ionic liquids (ILs) of quinolines, quinazolines and quinazolinones is described. All</div><div>mentioned green chemistry methods are gaining promising environmental and</div><div>economic benefits and are being a subject of many research these days.</div>