Application of Modern Analytical Techniques for Quantification of Tadalafil in Pharmaceutical and Biological Matrices: Future Prospectus

Abstract

Background: Analytical techniques play a vital role in developing patient-friendly dosage forms in the pharmaceutical industry. Presently, numerous sophisticated and highly delicate modern analytical instruments are available in pharmaceutical industries to assess active pharmaceutical ingredients or other excipients present in different pharmaceutical matrices and biological fluids. Assortment of the most suitable analytical techniques for analysing any component during the drug development process is challenging as it affects the final product's quality, safety, and efficacy. Introduction: Tadalafil (TDL) is the most flexible second-generation Phosphodiesterase-5 inhibitor. It treats erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension as first-line therapy, either alone or with other medications. This review paper aims to highlight the varieties of new analytical techniques (like UV-Visible spectroscopic technique, HPLC, HPTLC, Electroanalytical technique, Spectrofluorimetry, GC-MS, LC-MS) that have been reported for quantification of TDL as a single or in the combined form present in bulk material as well as in different biological or pharmaceutical matrices, their pros and cons, and future potential of such methods. Conclusion: This article's reported methods are accurate, sensitive, and cost-effective. Applying AQbD and green analytical chemistry with greener organic solvents and reagents in some of the reported methods opens a new era of analytical method development that will aid in future growth for the estimation of TDL.