Abstract
For safe and effective gene therapy,targeted tissue-restricted transgene expression is desirable.A new system which can regulate transgene expression,including viral gene expression,by exploiting microRNA (miRNA) has recently been developed.In miRNA-regulated transgene expression systems,tissue-specific miRNA recognition element are usually incorporated into the 3'-UTR of the transgene expression cassette,leading to the suppression of transgene expression in cells highly expressing the corresponding miRNA.The aim of this review is to highlight the mechanism of viral transgene expression systems for viral vaccine. Key words: MicroRNAs ; Transgene ; Virus ; Vaccine
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