Application of microneedles in dermatology

Abstract

Microneedles are a new transdermal drug delivery system(TDDS)derived from microelectro-mechanical systems.The needle-like structures in different materials and shapes,which have improved with the development of microelectronics industry and material science,can remarkably increase the permeability of drugs by forming minimal pores in stratum corneum.The traditional microneedle-based percutaneous collagen induction therapy is currently used to treat acne,as well as to improve cutaneous pigmentation,scars,wrinkles and skin tone.Recently,some advances have been achieved in the treatment of superficial skin tumors with microneedles.Due to their unique transdermal delivery mode,high security and portability,microneedles combined with topical medications will have a wide range of clinical applications in the treatment of some intractable superficial skin diseases. Key words: Microneedles ; Administration,cutaneous ; Therapeutic uses ;