Abstract
Micellar extraction was applied to isolate famotidine from aqueous samples. This drug is an H2 receptor antagonist used for the treatment of stomach diseases. The process was performed with a mixture of anionic sodium dodecylsulfate and nonionic Triton X-114 surfactants. The effect of different parameters on the efficiency of the micellar extraction such as electrolyte and surfactant concentration, pH of sample, temperature, shaking and centrifugation time was investigated. The influence of foreign substances on a studied process was tested. The elaborated procedure was applied for HPLC–UV determination of famotidine in natural water samples. The calibration graph was recorded in the range 1.35–37.12 μg mL−1 of the studied compound. The repeatability of the method was equal to 7.4%. The limit of detection and quantification values for the determination of famotidine by using the proposed method amounted to 0.40 and 1.25 μg mL−1, respectively.
Highlights
Micellar extraction (ME) is successfully used for isolation of a variety of analytes from different matrices [1,2,3,4]
It was observed that the addition of the non-ionic surface active agent: Triton X-114 enhanced the efficiency of micellar extraction
The most important advantage of the developed procedure in comparison to a classical liquid– liquid extraction is a significant decrease in the amount of the used organic solvent, and micellar extraction is relatively friendly to the environment
Summary
Micellar extraction (ME) is successfully used for isolation of a variety of analytes from different matrices [1,2,3,4]. The effect of different parameters on the efficiency of the micellar extraction such as electrolyte and surfactant concentration, pH of sample, temperature, shaking and centrifugation time was investigated. It was observed that the use of other values of concentration of surfactants during isolation of FMT, caused a decrease in the efficiency of micellar extraction of the studied analyte.
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