Abstract
Magnetically stabilized fluidized beds (MSFBs) have many advantages over current column separation techniques. The backmixing of solids seen in normal fluidized beds is eliminated, making countercurrent solids/fluid contact possible. Compared to the fixed bed, the MSFB allows continuous processing of the feed material while operating at a low bed pressure drop. Although other methods are available for carrying out continuous chromatographic separations, no other methods that we are aware of allow continuous bed treatment or replacement and few achieve a system which is as simple to operate. We have tested one application of MSFBs in bioprocessing: continuous affinity chromatography. The experimental results obtained using human serum albumin, Cibacron Blue F3GA®, and dried calcium alginate / magnetite beads agree with our mathematical model.
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