Abstract
Development of magnetic nanomaterials has greatly promoted the innovation of in-tube solid-phase microextraction. This review article gives an insight into recent advances in the modifications and applications of magnetic nanomaterials for in-tube solid-phase microextraction. Also, different magnetic nanomaterials which have recently been utilized as in-tube solid-phase microextraction sorbents are classified. This study shows that magnetic nanomaterials have gained significant attention owing to large specific surface area, selective absorption, and surface modification. Magnetic in-tube solid-phase microextraction has been applied for the analysis of food samples, biological, and environmental. However, for full development of magnetic in-tube SPME, effort is still needed to overcome limitations, such as mechanical stability, selectivity and low extraction efficiency. To achieve these objectives, research on magnetic in-tube SPME is mainly focused in the preparation of new extractive phases.
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