Abstract
A representative set of 46 secondary metabolites of plant and microbial origin was examined with electrospray and atmospheric pressure chemical ionization MS in both positive and negative ion mode, in order to evaluate the applicability of atmospheric pressure ionization LCMS as a tool for rapid identification and dereplication of bioactive compounds in the drug screening process. MS characteristics of different compound classes were determined on the basis of quasi-molecular ion and other adduct ion responses observed with the two LCMC interfaces. Interface parameters and LC mobile phase composition were optimized and an analytical protocol applicable to a wide range of secondary metabolites is proposed.
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