Abstract
A qualitative screening procedure was developed for the detection of the hydrolysis and related products of chemical warfare agents using liquid chromatography-mass spectrometry with atmospheric pressure chemical ionisation. A mixed C 8/C 18 reversed-phase column gave acceptable chromatography for the range of acidic, neutral and basic analytes. Detection limits for pure standards were less than 0.2 ng injected for the simple hydrolysis products of sulphur and nitrogen mustards, thiodiglycol sulphoxide, diisopropylaminoethanol and 3-quinuclidinol. Detection limits were in the range 0.2–8 ng injected for a series of alkylphosphonic acids and alkyl alkylphosphonic acids, and for benzilic acid. The methodology provides a rapid screening procedure for aqueous samples and extracts and was applied to the analysis of soil samples collected from bomb craters, and to spiked water and soil samples.
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