Abstract
Probiotic extracts have various positive attributes, such as antioxidant, tyrosinase inhibitory, and antimicrobial activity. Lactobacillus curvatus produces bacteriocin, which activates the lipid membrane structure and has potential as a natural preservative for cosmetic emulsions. In this study, L. curvatus extract was encapsulated in liposomes and formulated as an oil-in-water (O/W) emulsion. Radical scavenging activity, tyrosinase inhibition, and challenge tests were conducted to confirm the liposome activity and the activity of the applied lotion emulsion. The liposome-encapsulated extract had a relatively high absolute ζ-potential (52.53 > 35.43), indicating its stability, and 96% permeability, which indicates its potential as an active agent in lotion emulsions. Characterization of emulsions containing the liposomes also indicated a stable state. The liposome-encapsulated extract exhibited a higher radical scavenging activity than samples without the extract and non-encapsulated samples, and the functionality was preserved in the lotion emulsion. The tyrosinase inhibition activity of the lotion emulsion with the liposome-encapsulated extract was similar to that of the non-treated extract. Candida albicans and Aspergillus niger were also inhibited in the challenge test with the lotion emulsions during storage. Collectively, these findings indicate that the liposome-encapsulated extract and the lotion containing the encapsulated extract have potential applicability as natural preservatives.
Highlights
The cosmetics industry has developed and become extremely diverse [1]
The prepared liposomes were characterized by measuring their particle size and zetapotential
The encapsulation efficiency of the the treatments (p < 0.05). These results show that encapsulation with liposomes protected liposomes was determined by treatment with propidium iodide to stain the nucleic acid probiotic the effects of fully highencapsulated rotating speed, which generates heat and forthe evaluation
Summary
The cosmetics industry has developed and become extremely diverse [1]. One industry trend is the use of natural cosmetics for personal care [2]. Personal care cosmetic products such as creams and lotions are based on oil-in-water (O/W) emulsions formulated with natural ingredients Chemical preservatives, such as sodium ethylene diamine tetraacetic acid (Na EDTA), are often added because it is difficult to safely distribute the products to consumers without preservatives. Probiotics such as Lactobacillus and Leuconostoc have taken center-stage as cosmetic ingredients [3]. Useful metabolites produced by probiotics are found in extracts and have various functions, such as antioxidant and tyrosinase inhibitory activity, which induce skin whitening effects [6] These extracts can potentially be exploited as multifunctional natural preservatives for use as cosmetic ingredients.
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