Abstract
Considerable attention has been paid to the analysis of chemicals in the s-triazine group, due to their widespread use in agricultural chemistry and their subsequent impact on biological systems. For initial chemical screening of the activity of newly synthesized compounds, it is recommended to determine their lipophilicity and physico-chemical property in relation to biological activity. Lipophilicity is difficult to quantify. The most widely accepted measure of lipophilicity is the octanol-water partition coefficient. Measurement of the octanol-water partition coefficients is achieved by an alternative method, i.e. reversed-phase liquid chromatography. Reversed-phase thin-layer chromatography (RP TLC) is a rapid method for the analysis of large number of s-triazine type compounds. Certain relationship between the structure of s-triazine compounds and their mobility on silica gel impregnated with paraffin oil have recently been demonstrated. The retention behavior of compounds in various chromatographic systems strongly depends on their physico-chemical properties. Recently, much effort was given in finding adequate mathematical model relating the retention of the given analyte to its physico-chemical and structural parameters (descriptors). These correlations are known as quantitative structure-retention relationships (QSRR), which offer a powerful tool for the prediction of separation behavior. The QSRR equations describing retention constants RM0, determined for different modifiers in mobile phase in terms of logarithms of n-octanol-water partition coefficients, were derived. The partition coefficients (AlogPs, AClogP, AB/logP, milogP, AlogP, MlogP, logPKowin, XlogP2, XlogP3, ACDlogP i ClogP) were calculated by application of different software packages. The goal of this paper was to select the logP data and TLC system that best characterize octanol/water partitioning and thus the lipophilicity of the investigated molecules.
Highlights
Sadrži alat koji nije dostupan u nekim drugim komercijalnim paketima za crtanje, uključujući i alat za prikaz 2D strukture, 3D optimizaciju i pregled, kao i imenovanje molekula
The quantitative structure–retention relationships (QSRR) equations describing retention constants RM0, determined for different modifiers in mobile phase in terms of logarithms of n-octanol-water partition coefficients, were derived
Summary
Herbicidi su proizvodi hemijskog ili biološkog porekla koji su namenjeni zaštiti biljaka od korova i predstavljaju veoma heterogenu i brojnu grupu jedinjenja. Savremeni pristup dizajniranju novih biološki-aktivnih supstanci zasniva se na utvrđivanju veze između hemijske strukture jedinjenja i njihove biološke aktivnosti [7]. Da bi se dobile zadovoljavajuće korelacije koje imaju fizičkog smisla, veoma je važan izbor parametara molekula koji će se primenjivati. Parametri molekula koji numerički izražavaju odgovarajuće fizičko-hemijske osobine nekog jedinjenja zovu se molekulski deskriptori [11]. Podeoni koeficijent u sistemu oktanol–voda, log Kow, koji se često izražava kao log P [12,13]. Podeoni koeficijent se može izračunati na osnovu hemijske strukture molekula primenom različitih računarskih metoda, ali i odrediti eksperimentalno, metodom mućkanja. S obzirom na to da su podeoni koeficijenti u direktnoj vezi sa hromatografskim podeonim retencionim parametrima, u poslednje vreme sve se više pažnje posvećuje hromatografskim parametrima kao meri lipofilnosti [14,15]
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