Application of Lifeport machine perfusion in preservation of the grafted kidneys from donation after citizen death old age donors

Abstract

Objective To explore clinical application efficacy of Lifeport machine perfusion in improving the quality of elderly donor kidneys from donation after citizens death (DCD). Methods The clinical data of 47 DCD kidney donors more than 60 years old in our center from January 2013-December 2015 were retrospectively analyzed. The donors were divided into hypothermic mechanical perfusion group (HMP) group (n=32) and static cold preservation group (SC) (n=15) accordance with kidney preservation methods. The incidence of postoperative one-year delayed graft function (DGF), blood creatinine and the survival rate of the renal grafts were compared between two groups. Results The incidence of DGF in HMP group (6.3%) was decreased as compared with SC group (13.2%) (P<0.24). The average length of hospital stay in HMP group was 16.6 days, shorter than in SC group (P=0.37). One year after renal transplantation, the average blood creatinine level in HMP group was lower than in SC group (125.8 μmol/L vs. 198.6 μmol/L, P=0.42). The 1-year graft survival rate in HMP group was higher than in SC group (96.9% vs. 80%, P=0.057). Conclusion Lifeport machine perfusion preservation can objectively evaluate the renal function of elder DCD donors and improve quality of donor kidneys. Key words: Kidney transplantation; Donor; Elderly; Kidney; Machine perfusion