Abstract

Lentiviral vectors can effectively transduce dividing and nondividing cells,insert large genetic segments into the host chromatin and sustain long-term stable transgenetic expression.They are widely used as gene dilivery vectors.The article reviews the development of lentiviral vectors and its application in genetic engineering such as gene therapy,induction of pluripotent stem cells,cell imaging,transgenic animals,and animal models. Key words: Lentivirus; Vectors; Genetic engineering; Gene therapy

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