Application of laser-induced fluorescence method to the study of the cerebral aneurysm wall: First results and perspectives

Abstract

Identification of the mechanical properties of the vascular tissue plays an important role in modern tasks of preoperative modeling of cerebral aneurysms. The aim of the study was to determine whether differences in the structure of healthy, unruptured and ruptured aneurism tissues can be demonstrated by laser-induced fluorescence spectroscopy. Tunable laser (210-290 nm) induced fluorescence exhibit contributions of at last four components, which were identified using narrow peak modification of principal component analysis. The pathology development shows a tendency to relative component contributions redistribution. The ultraviolet laser-induced fluorescence spectroscopy of cerebral vessel surfaces may be useful for identifying its medical condition.Identification of the mechanical properties of the vascular tissue plays an important role in modern tasks of preoperative modeling of cerebral aneurysms. The aim of the study was to determine whether differences in the structure of healthy, unruptured and ruptured aneurism tissues can be demonstrated by laser-induced fluorescence spectroscopy. Tunable laser (210-290 nm) induced fluorescence exhibit contributions of at last four components, which were identified using narrow peak modification of principal component analysis. The pathology development shows a tendency to relative component contributions redistribution. The ultraviolet laser-induced fluorescence spectroscopy of cerebral vessel surfaces may be useful for identifying its medical condition.