Application of keratoxenoimplant in the cases of experimental chemical burn of the cornea associated with hypothyroidism

Abstract

<p>The article analyzes the efficacy of keratoimplant of pigs in rabbits with corneal chemical burns with underlying<br />merkazolil-induced hypothyroidism. Hypothyroidism in rabbits was caused by injection of merkazolil at a dose of<br />10 mg/kg during 60 days. Chemical burn of the cornea was simulated by applications on the cornea of experimental<br />animals filter paper of 5 mm in diameter soaked in a solution of 1 N sodium hydroxide (NaOH) during 30 seconds.<br />With the purpose of surgical correction the place of burn injuries was covered with keratoxenoimplant which was sewn<br />in 4 places (after 12, 15, 18 and 21 hours) to the sclera through the conjunctiva with the help of atraumatic needle<br />8/0 nylon. It was established that corneal burn injury in rabbits with hypothyroidism ran against the background of<br />oppression of nonspecific factors of protection, more expressive growth of endogenous intoxication, depression of<br />antioxidant protection as compared to euthyroid animals with simulated chemical burn of the cornea. Application of<br />keratoxenoimplant contributed to the normalization of the studied parameters and faster healing of burn wounds. It<br />was concluded that the application of keratoxenoimplant under conditions of chemical burn of the cornea positively<br />affected the course of the burn process and promoted more rapid restoration of the integrity of the cornea.</p>