Abstract
A simple titrimetric method is described for the determination of dothiepin hydrochloride. The method is based on titrating the cited drug with potassium salts of trioxalato-ferrate (III) (TOXFe), trioxalato-chromate (III) (TOXCr), trioxalatoaluminate (III) (TOXAI) and trioxalato-cobaltate (III) (TOXCo). The end point was located conductimetrically. The effect of solvent, molar ratio, reagent concentration and temperature were studied. Based on conductimetric measurements at 25 °C, the solubility, solubility product, free energy (ΔG) and entropy changes (ΔS) of the ion associates were calculated. Calculations of the enthalpy change (ΔH) are based on atomic absorption measurements of the solubility of the ion associates at different temperatures. The method allowed the determination of 6.63-29.87, 3.31-49.78, 9.95-49.78 and 3.31-33.19 mg of the studied drug using TOXFe, TOXCr, TOXAl and TOXCo, respectively. The method was further applied successfully to some dosage forms containing the cited drug, and the obtained results were compared favorably with those previously given by the official method.
Highlights
Dothiepin hydrochloride [ I897-15-41 (Doth.CI) has properties typical of the drugs known as antidepressants which are widely used for treating of depressive diseases
Solutions that contain many mobile ions conduct electric current well, and solutions that contain few or relatively immobile ions conduct electric current poorly. In this manner the conductance of solutions provides another method by which changes in the composition in solutions can be detected and another method of end point detection
The titration curve, which is a relation between the conductance and the volume of titrant added, can be represented by two lines intersecting at the end point
Summary
Dothiepin hydrochloride [ I897-15-41 (Doth.CI) has properties typical of the drugs known as antidepressants which are widely used for treating of depressive diseases. Several techniques have been adopted for the determination of dothiepin including non-aqueous titration using perchloric acid [ I ] and sodium dodecyl sulphate [2], extractive [3], derivative [4] and kinetic [5] spectrophotometry, voltammetry 161, capillary electrophoresis [7],HPLC [8] and GC [9]. There are no literature data about using of trioxalato complexes in determination of drugs. The present work, aims to introduce a new and simple conductimetric method for the determination of Doth.CI. This method is very simple in application and of low expenses in comparison with some of the above techniques
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