Abstract
BackgroundInternet of Things (IoT), or Industry 4.0, represents a smart shift to more interconnected manufacturing processes where individual entities within the supply chain communicate with each other to achieve greater flexibility and responsiveness in general manufacturing and leaner manufacturing to reduce the cost of production. IoT has become instrumental in driving leaner manufacturing and more efficient systems in other industries such as transportation and logistics. Cell-based therapeutic products could potentially transform various diseases; however, the delivery of these products is complex and challenging.ObjectiveThis study aims to understand the applicability of IoT in cell-based product supply chains and delivery.MethodsWe will search Medline, EMBASE (OvidSP), Web of Science, Cochrane Library & HEED, Scopus, ACM digital library, INSPEC, ScienceDirect, and the IEEE Xplore Digital Library for studies published after 2008 using a combination of keywords and subject headings related to IoT used in cell therapies. Additionally, a Google search to identify gray literature will be conducted. Two authors will independently screen the titles and abstracts identified from the search and accept or reject the studies according to the study inclusion criteria. Any discrepancies will then be discussed and resolved. The quality of the selected literature will be assessed using the Critical Appraisal Skills Programme systematic review checklist.ResultsData from eligible publications will be abstracted into a predesigned form to map the current and future directions of the technologies, applications, benefits, and challenges in the implementation of IoT in regenerative medicine. This study will be published in a peer-reviewed journal in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This systematic review will be executed by June 2020, and the completed review will be published in a peer-reviewed journal to inform future developments in IoT application for the delivery of cell-based therapies.ConclusionsThis review paper will provide an overview of all technologies available in the area and inspect the current IoT applications in cell-based therapies to identify the benefits, challenges, and future directions of using IoT to allow safe and cost-effective delivery of cell-based therapies.International Registered Report Identifier (IRRID)PRR1-10.2196/16935
Highlights
BackgroundInternet of Things (IoT) is a concept first proposed by Ashton [1] at a presentation at Procter & Gamble (Cincinnati, Ohio) in 1999
Over the last two decades, IoT has been successfully implemented in various industries including aerospace, aviation, automotive, telecommunications, medicine and health care, independent living, pharmaceutical, retail, logistics and supply chains, manufacturing, process, environmental, transportation, agricultural and breeding, media and entertainment, recycling, and insurance [2,3]
This paper aims to systematically review all technologies available in the area, and inspect the current IoT application in cell-based therapies to identify the benefits, challenges, and future directions of using IoT to allow safe and cost-effective delivery of cell-based therapies
Summary
Internet of Things (IoT) is a concept first proposed by Ashton [1] at a presentation at Procter & Gamble (Cincinnati, Ohio) in 1999. Constant monitoring and real-time data acquisition and analysis lead to benefits such as earlier detection of risks, faster response times, and cost savings. This has a wide range of usages from mine production safety [4] to home health care applications [5]. To allow successful implementation of IoT, the challenges specific to the area have to be identified Issues such as privacy and security encountered in other IoT applications [19] have to be identified and considered in a manner specific to cell therapy manufacturing and delivery to inform a tailored IoT approach that facilitates translation and delivery of cell-based products. This paper aims to systematically review all technologies available in the area, and inspect the current IoT application in cell-based therapies to identify the benefits, challenges, and future directions of using IoT to allow safe and cost-effective delivery of cell-based therapies
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