Application of Intelligent Monitoring of Percutaneous Partial Oxygen Pressure in Evaluating the Evolution of Scar Hyperplasia.

Zhuoma Dawa,Yanan An,Mejia Zhuo,Wanle Qi,Junjie Bao,Balakrishnan Nagaraj,Yan Tian

doi:10.1155/2021/8241193

Zhuoma Dawa, Yanan An + Show 5 more

Open Access

https://doi.org/10.1155/2021/8241193

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Abstract

The study aimed to investigate the dynamic changes of percutaneous partial oxygen pressure during the development and evolution of a hypertrophic scar. Twenty cases of hypertrophic scar patients at different stages were selected. A percutaneous oxygen monitor was used to measure oxygen partial pressure in the scar and normal skin tissue at 14, 30, 60, and 90 days after surgery. The changes of oxygen partial pressure, tissue structure, HIF-1α, and VEGF expression in the scar tissue were observed, and the correlation was analyzed. In the scar maturation process, with the prolongation of time, the partial oxygen pressure in the tissue increased gradually. The expression intensity of HIF-1α and VEGF decreased gradually, HIF-1α was positively correlated with VEGF (r = 0.98, P < 0.01), there was a negative correlation between oxygen partial pressure and HIF-1 α expression (r = −0.92, P < 0.01), and it was negatively correlated with VEGF (r = −0.88, P < 0.01). TcPO2 measurement can be used to assess scar maturity; HIF-1 α and VEGF may play an essential role in regulating partial oxygen pressure in the scar tissue.

Highlights

Hypertrophic scar (HYPERtrophic scar) is a kind of hyperhyperplastic fiber disease after skin tissue damage
Expression were observed, and the correlation between them was analyzed. e results showed that the partial oxygen pressure in the tissue increased gradually with the prolongation of time, and the expression intensity of HIF-1α and VEGF decreased gradually
HIF-1 α was positively correlated with VEGF (r 0.98, P < 0.01). e partial oxygen pressure in tissues was negatively correlated with hiF-1 α expression (r −0.92, P < 0.01) and negatively correlated with VEGF (r −0.88, P < 0.01)

Summary

Introduction

Hypertrophic scar (HYPERtrophic scar) is a kind of hyperhyperplastic fiber disease after skin tissue damage. Its histological characteristics are the proliferation of fibroblasts (FB) and extracellular matrix (ECM), especially the excessive deposition of collagen polysaccharides and glycoproteins. Microvascular dysplasia is accompanied by a small amount of inflammatory cell infiltration and collagen fiber disorder [1]. Proliferative paralysis is a local morphological change. Excessive contraction of paralysis has symptoms such as cramps, itching, and tingling. Contracture of paralysis marks in the joints often limits the functional movement of the limb

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