Abstract
With a view to developing biomedical materials for reconstructive surgery, we have studied a composite material constituted with collagen and a synthetic polymer, which possesses high tissue compatibility (1). We have been also investigating the replacement of various organs with this new material experimentally and clinically, for example for reconstruction of the trachea, chest wall, or diaphragm (2). This collagen-synthetic polymer composite material was applied as a support for immobilization of enzymes to provide the material surface with biological functions. Enzymes were successfully bound to the collagen membrane layer by activation of its carboxyl groups. We have already described the in vitro and in vivo behavior of urokinase immobilized on this composite material (3). When artificial organs and biomedical materials are implanted in the body, bacterial infection may cause serious complications. We now report a new method for producing antibacterial biomedical materials by immobilization of lysozyme and a polypeptide antibiotic Polymyxin B on this composite material.
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