Abstract
Objective To investigate the application of human papilloma virus (HPV) E6/E7 mRNA test to process atypical squamous cells of undetermined significance (ASC-US) in layers.Methods 312 patients with ASC-US underwent HPV E6/E7 mRNA test.The pathology data was statistically analyzed.Results Stratified by pathology,the positive rate of HPV E6/E7 mRNA was 43.40％ in 211 patients (67.63％) with inflammation or normal,71.21％ in 66 patients (21.15％) with LSIL (low-grade squamous intraepithelial lesion) and 91.18％ in 35 patients (11.22％) with HSIL (high-grade squamous intraepithelial lesion).Among the detection efficiency of HPV E6/E7 mRNA test for ISIL/HSIL,the sensitivity was 78.22％,the specificity was 56.40％,positive predictive value (PPV) was 46.20％,and negative predictive value (NPV) was 84.40％.Conclusion HPV E6/E7 mRNA test can be well used in hierarchical processing of ASC-US to avoid the misdiagnosis of high-grade cervical lesion. Key words: Human papilloma virus; E6/E7; Atypical squamous cells of undetermined significance; Squamous intraepithelial lesion
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