Application of homocysteine, hypersensitivity C reactive protein and N terminal pro brain natriuretic peptide in the diagnosis of chronic heart failure

Abstract

Objective To investigate the serum homocysteine (HCY), high sensitive C reactive protein (hs-CRP) and N terminal pro brain natriuretic peptide (NT-proBNP) levels in patients with chronic heart failure (CHF). Methods Seventy elderly patients with CHF were enrolled in this study from July 2015 to November 2016 in Gaoming District People's Hospital of Foshan City, Guangdong Province. Seventy cases of healthy elderly people were selected as the control group. Two groups of subjects were tested and compared the levels of HCY, hs-CRP and NT-proBNP in patients with different NYHA grades. The correlation between HCY, hs-CRP, NT-proBNP and NYHA classification were analyzed. The t test was used between the two groups, multiple groups were analyzed by ANOVA, and multiple comparisons were performed using the SNK-q test, the correlation was analyzed by bivariate Pearson linear correlation. Results The average levels of HCY, hs-CRP and NT-proBNP in the observation group was significantly higher than that in the control group, the difference was statistically significant (t=13.490, 12.428, 31.235; P < 0.05). There were significant differences in the levels of HCY, hs-CRP and NT-proBNP among patients with different grades of NYHA (F=1.245, 1.367, 26.524; P < 0.05). Further analysis shows that the NYHA grade III and IV patients’ HCY, hs-CRP and NT-proBNP were significantly higher than the average water level II patients. The differences were statistically significant (q=4.211, 4.194, 15.626, 10.401, 9.334, 37.832; P < 0.05). NYHA grade IV patients’ HCY, hs-CRP and NT-proBNP were significantly higher than the NYHA grade III patients. The differences were statistically significant (q=5.542, 5.764, 18.380; P < 0.05). Bivariate Pearson linear correlation analysis showed that the HCY, hs-CRP and NT-proBNP in the observation group were positively related to the cardiac function and NYHA classification (r=0.142, 0.643, 0.274; P < 0.05 or 0.01). Conclusion HCY, hs-CRP and NT-proBNP can be used as an important reference for clinical diagnosis and disease evaluation of elderly patients with CHF. Key words: Chronic heart failure; Diagnostic techniques and procedures; Hypersensitivity C reactive protein; N terminal pro brain natriuretic peptide; Homocysteine