Abstract
Hyperbranched biopolymers is an important class of polymer that is used in different areas, mainly in biomedicine. AB2 monomers are crucial to the development of a architecture of polyglycerol, being glycidol the most commonly used, even considering its environmental hazard. Glycerol carbonate is an ecologically accepted monomer synthesized directly from glycerol, and the chosen for the studies herein. In literature, no studies described the use of glycerol and cyclic carbonates to prepare hyperbranched polymers. This work describes the obtainment of hyperbranched polymers using glycerol and TMP salt as core-initiator and glycerol carbonate and propylene carbonate as monomers. The polymers were characterized by FTIR, NMR, MALDI-TOF and TEM. NMR spectroscopy showed linear, dendritic, and terminal units of hyperbranched polymer. The degree of branching PGLYGC and PTMPGC was 0.669 and 0.667, respectively. The molecular weight of PTMCGC, PTMPPC, PGLYPC was found and compared with MALDI. The molar mass was not different from the calculated by Inverse Gated. These polymers have enormous potential as drug delivery and an environmentally correct synthetic route due to the substitution of glycidol by biocompatible monomers.
Highlights
Over the past decade, attention on the use of biopolymers has grown enormously such as hyperbranched polymers or dendrimers due to proven potential as drug delivery due to biocompatibility, degradability and absorbability properties, and in medicinal engineering[1,2,3].The synthesis of dendrimers is very laborious because involves multiple steps of protection/deprotection and complex purification[4]
In front of the above reports we have described in this work, the obtainment, characterization and mechanism of hyperbranched polyglycerol using glycerol and 1,1,1-tris(hydroxymethyl)propane salt as initiator, glycerol carbonate as a AB2-type monomer and propyl carbonate as a AB1-type monomer
The polymers structures were proposed by Nuclear Magnetic Resonance (NMR) techniques as well as their molecular weights
Summary
Attention on the use of biopolymers has grown enormously such as hyperbranched polymers or dendrimers due to proven potential as drug delivery due to biocompatibility, degradability and absorbability properties, and in medicinal engineering[1,2,3].The synthesis of dendrimers is very laborious because involves multiple steps of protection/deprotection and complex purification[4]. These polymers are macromolecules with a random branching topology with compact dimensions, which are part of a special class of dendritic macromolecules[5] They have similar structures and properties to the dendrimer, such as intrinsic compact structure, large number of terminal groups, low viscosity compared to similar straight chain polymers, and high solubility[6]. This class of polymers has the attention of the scientific community due to their capacity as "drug delivery", since it improves important therapeutic properties, such as: insolubility of drugs in water, bioavailability, biocompatibility, biodegradability[7]. Their properties showed to be better in comparison to polyethylene glycol, an industrial drug carrier, due to low toxicity, low immunogenicity as well as due to increasing camouflage against mononuclear phagocyte system (MPS)[8,9,10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
