Application of Gallic Acid Enhances Alveolar Socket Healing

Abstract

Back ground:Alveolar bone regeneration can be guided by the application of a Gallic acid following tooth extraction. Aim of the study:The present study was designed to evaluate the histological and immunohistochemical aspects of socket healing in extraction site received Gallic acid ,compared with control site that healed spontaneously. Materials and Method: Twelfth Sprague-Dawley male rats were subjected for a surgical tooth extraction of upper central teeth of both sides .The right side be the control one as the socket healed spontaneously. while left side treated with 3?L of Gallic acid. The rats were scarified at 14and 28days post extraction. Socket healing was examined histologically and evaluate immuno-expression of osteocalcin. Results: Experimental site illustrates trabecular bones formation between the peripheral and central regions of the sockets at 14 day and increment of bone formation was observed , filled most of socket at 28 days. Results show intense positive expression of osteocalcin by bone cell in experimental group in comparisum to control.The results confirmed by statistic analysis of the data ,which revealed a high significant difference in the mean of positive cells specifically at day 14 postoperative. Conclusion: The present study ,high lighted on osseo-inductive and angiogenesis effect of the local application of gallic acid in socket healing.