Application of endoscopic ultrasound guided needle biopsy in patients with pancreatic tumor

Abstract

Background: Pancreatic cancer is a rapidly progressive disease, low 5-year survival rate (less than 11%). However, if pancreatic tumors detected and treated early, the 5-year survival rate improves significantly. The diagnosis of pancreatic cancer, besides conventional imaging measures. It has been a challenge to obtain a histopathological gold standard for the diagnosis of pancreatic cancer. The advent of endoscopic ultrasound and endoscopic ultrasound guide fine-needle biopsy (EUS-FNB) has created a major turning point in the histopathological diagnosis of pancreatic tumors. In Vietnam, there have not been many announcements about the effectiveness and safety of this technique. Objectives: 1. To evaluate the effectiveness and safety of EUS-FNB procedure in patients with pancreatic tumor; 2. To investigate some related factors between EUS-FNB procedure and histopathological results. Subjects and methods: Descriptive cross-sectional study on patients who had a pancreatic tumor or suspected pancreatic tumor and underwent EUS-FNB at the endoscopy department of Cho Ray Hospital from January 1th, 2021 to October 15th 2021. Results: There were 97 pancreatic tumor patients who underwent EUS-FNB, without significant complications. 80.4% of patients had histopathological result to diagnose the tumor nature, 19.6% patients had no tumor cells in the specimen. FNB with 19G needle gave higher histopathological results than 22G needle (p < 0.01). There was a significant difference in histopathological results between the tissue sample length segments obtained < 4 mm, 4 - 7 mm and ≥ 8 mm. Conclusion: EUS-FNB is effective and ralatively safe procedure in patients with pancreatic tumor. There was a significant relationship between the needle size for FNB, the length of the tissue obtained with the histopathological results. Key words: Endoscopic Ultrasound, Pancreatic tumor, EUS-FNB