Abstract
In the paper, electromembrane extraction (EME) method coupled with corona discharge ion mobility spectrometry (CD-IMS) was introduced for determination of antidepressant drugs (desipramine, sertraline, clomipramine, citalopram) in urine samples. IMS is a well-known, comparatively inexpensive, robust and easy to operate analytical instrumentation. This combination would provide a selective and sensitive determination. In order to achieve the best extraction efficiency, optimization of the variables affecting these methods was carried out. Optimal extractions were accomplished with 2-nitrophenyl octyl ether as the supported liquid membrane, with 190V as the driving force, and with pH4 in donor and pH1 in acceptor solutions. Extractions were obtained after 30min of operation with the whole assembly agitated at 1000rpm.Under the optimized conditions, the proposed technique provided good linearity (>0.9974), repeatability (RSD<4.5%), low limits of detection (0.9–1.5ngmL−1), excellent preconcentration factor (PF=158–190) and high recoveries (79–95%). Finally, developed method was applied to quantification of antidepressant drugs in urine samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
