Abstract
An on-line LC/MS system with a semimicro HPLC and a direct liquid introduction LC/MS interface was applied to the investigation of both positive and negative chemical ionization mass spectra of compounds that contain hydroxyl and carboxyl functional groups or halogen atoms. These mass spectra had a characteristic of yielding significant quasi-molecular ions (M+H)+ and (M-H)-, and the molecular ion M- corresponding to their molecular structure. Furthermore, this LC/MS system was experimentally proved to provide LC/MS routine analysis capability for some drugs which contain several components, making it possible to separate those components and determine their molecular weights.
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