Abstract
Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulate-based drug delivery and imaging systems. The smaller size (~7–12 nm) of dendrimers have the advantage over the other particles, because its smaller size can possibly improve tumor penetration and the inclusion of tumor specific drug release mechanisms. A Paramagnetic Chemical Exchange Saturation Transfer (PARACEST) MRI contrast agent, Eu-DOTA-Gly4 or a clinical relevant Gd-DOTA was conjugated on the surface of a G5 PAMAM dendrimer. To create a dual mode MRI-optical imaging nanoparticle, Dylight680 was also incorporated on the amines surface of a G5 dendrimer. The particle was detected with in vivo MRI in preclinical glioma animal model. Furthermore, noninvasive imaging results were validated with in vivo and ex-vivo optical imaging.
Highlights
Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulate-based drug delivery and imaging systems
There are many ways a relaxation agent can be confined to the vascular bed including conjugation of a simple chelate such as DOTA or DTPA to high molecular weight macromolecules such as albumin, polylysine, or dendrimers of various sizes, prepare large nanoparticles such as iron oxide particles (SPIOs, USPIOs)
The in vivo effect of dendrimer-based Gd-DTPA contrast agents depends on the dendrimers core, size and the external surface charge [19,20]
Summary
Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulate-based drug delivery and imaging systems. Keywords Glioma; Tumor blood-brain barrier; Dual modality; CEST MRI; Optical imaging; Malignant Glioma Imaging We briefly discuss the applications of dendrimer-based nanoparticles for brain cancer imaging.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
