Abstract
Objective To assess the contrast-enhanced ultrasound (CEUS) characteristics of pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA). Methods A retrospective analyse was made from the contrast-enhanced ultrasonic features of 42 PA and 8 CXPA. The features included tumor size, echotexture, boundary, shape and blood flow richness on conventional US imaging and rise time (RT), time to peak (TP), peak intensity(PI), time from peak to one half(HT), mean transit time (MTT), and area under the curve(AUC) on contrast-enhanced ultrasound. Results All of PA and CXPA were hypoechoic, but there was no difference between them in shape and blood flow richness (P>0.05). 37.5% CXPA has hetergeneous echotexture with the presence of anechoic area, but it appeared in only 4.8% PA(P 0.05). Conclusions Conventional US and CEUS perfusion patten provide limited diagnostic information for distinguishing PA from CXPA. CXPA could be diagnosed by ill-defined margins, more internal anechoic area and poorly defined margins. But CEUS quantitative analysis can significantly promote the differentiation. Key words: Contrast-enhanced ultrasound; Salivary gland neoplasms; Pleomorphic adenoma
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