Abstract
Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013
Highlights
Ng et al reported that a decoction of Gastrodiae Rhizoma was able to protect against in vivo and in vitro neurotoxicity induced by beta-amyloid through the inhibition of apoptosis and oxidative damage
The authors suggested that the protective effect of isorhynchophylline against beta-amyloidinduced cytotoxicity in PC12 cells was associated with the enhancement of p-CREB expression via PI3K/Akt/GSK-3β signaling pathway
Subsequent biological tests conducted by the research team showed that acetylshikonin was the most effective compound among these acetylcholinesterase inhibitors in preventing apoptosis induced by hydrogen peroxide in neuronal SH-SY5Y and PC12 cells
Summary
Editorial Application of Complementary and Alternative Medicine on Neurodegenerative Disorders 2013 Paul Siu-Po Ip,[1] Karl Wah-Keung Tsim,[2] Kelvin Chan,[3,4] and Rudolf Bauer[5] Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive loss of neurons in sensory, motor, and cognitive systems.
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