Application of colonic irrigation of metronidazole combined with 5-FU in the one-stage resection and primary anastomosis to treat the left colonic neoplasms with intestinal obstruction

Abstract

Objective To study the application effect of colonic irrigation of metronidazole combined with 5-FU in the one-stage resection and primary anastomosis to treat the left colonic neoplasms with intestinal obstruction.Methods 200 patients from March 2000 to May 2010 with the left colonic neoplasms with intestinal obstruction in our hospital were randomly divided into the experimental group and the control group.The control group with 100 patients was treated with regular one-stage resection and primary anastomosis while the experimental group with 100 patients was treated with one-stage resection and primary anastomosis and colonic irrigation of metronidazole combined with 5-FU.The clinical curative effect was observed and compared.Results The incidence rate of complication and length of hospital time of the experimental group were obviously lower than those of the control group.There was statistically significant difference between two groups(P ＜ 0.05).Conclusion Colonic irrigation of metronidazole combined with 5-FU in the one-stage resection and primary anastomosis to treat the left colonic neoplasms with intestinal obstruction can lower the incidence rate of complication and fasten the heal of the anastomosis. Key words: Metronidazole combined with 5-FU; Colonic irrigation; One-stage resection and primary anastomosis; Left colonic neoplasms with intestinal obstruction