Abstract
BackgroundClick chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative example where click chemistry showed its promising potential. Challenging trials with nanoparticles has been reported based on click chemistry including copper-catalyzed cycloaddition, strain-promoted azide-alkyne cycloaddition, and inverse-demand Diels-Alder reaction.Main bodyHerein, we provide an update on recent application of click chemistry in nanoparticle research, particularly nanoparticle modification and its targeted delivery. In nanoparticle modification, click chemistry has been generally used to modify biological ligands after synthesizing nanoparticles without changing the function of nanoparticles. Also, click chemistry in vivo can enhance targeting ability of nanoparticles to disease site.ConclusionThese applications in nanoparticle research were hard or impossible in case of traditional chemical reactions and demonstrating the great utility of click chemistry.
Highlights
Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality
This paper demonstrated that the distribution and tumor-targeting of nanoparticles could be controlled by click chemistry in vivo
Click chemistry is suitable for these purposes and used to attach ligands to nanoparticles
Summary
Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Attachment of targeting ligands such as antibody, peptide, or aptamer can increase the binding of nanoparticles to the specific receptors on the surface of the target disease cells resulting in further enhance the targeting efficacy [10]. We will introduce the application of click chemistry in modification or targeted delivery of nanoparticles for imaging or drug delivery (Scheme 1).
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