Application of CKD-EPI equation to estimate glomerular filtration rate in Chinese elderly patients with chronic kidney disease

Abstract

Objective To evaluate the applicability of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate in Chinese elderly patients (≥ 65) with chronic kidney disease.Method 146 elderly patients (≥ 65) with CKD were evaluated for the correlation between eGFR and sGFR.Results Correlation analysis revealed eGFR was positively correlated with sGFR (r =0.776,P ＜ 0.01).The significant correlation between eGFR and sGFR existed both when sGFR ＜ 60 ml/(min · 1.73 m2) and when sGFR ＞ 60 ml/(min · 1.73 m2).Average deviation of eGFR from sGFR was (-1.79 ± 13.42) ml/(min · 1.73 m2).There was no significantly statistical deviation both in general and the point with 60 ml/(min · 1.73 m2) as the diagnostic cut-off point.15％,30％ and 50％ coincidence rates of eGFR were 43.15％,69.86％ and 86.99％ respectively.The coincidence rate of eGFR in sGFR ＞ 60 ml/(min · 1.73 m2) was higher than that in sGFR ＜ 60 ml/(min · 1.73 m2).Conclusions CKD-EPI equation has a less deviation and a higher accuracy for evaluation of GFR in elderly patients (≥ 65) with CKD.When estimating GFR at higher values,it may be underestimated by CKD-EPI equation.So,more prospective and multiple medical center should include large subjects to further assess the usefulness of CKF-EPI equation in estimating GFR in Chinese elderly patients (≥ 65) with CKD. Key words: Chronic kidney disease; Glomerular filtration rate; Assessment formula