Abstract
Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.
Highlights
Citicoline is an abbreviation of cytidine-50 -diphosphocholine (CDP-choline)
The application of appropriate rehabilitation, support, and neuroprotective treatment may reduce its harmful effects and facilitate recovery, or at least amend the functioning of the patient [20]
The following scales are used to assess the effectiveness of the applied therapy: Barthel index (BI), National Institute of Health Stroke Scale (NIHSS), and modified
Summary
Citicoline is an abbreviation of cytidine-50 -diphosphocholine (CDP-choline). Citicoline is globally available as a dietary supplement and in many countries as a drug. It can be bought as a tablet or an injection. Citicoline is degraded to cytidine and choline during hydrolysis and dephosphorylation. Cytidine and choline are substrates for phosphatidylcholine and CDP-choline synthesis in neurons. The detailed mechanism of citicoline functioning is not well understood [1,2]. Citicoline has minimal toxicity and is rapidly metabolized. Citicoline safety has been repeatedly proven in research based on animals [3]
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