Abstract
Hepatocellular carcinoma has a low early diagnostic rate,and there is a lack of highly sensitive and specific tumor markers. In recent years,fluid biopsy technique,represented by circulating free DNA( cfDNA),has become an auxiliary method for the diagnosis of cancer and has attracted more and more attention due to its advantages of noninvasiveness,convenience,and repeatability. With reference to the recent studies in China and foreign countries,this article summarizes and analyzes the advances in cfDNA in the diagnosis and treatment of hepatocellular carcinoma from the aspects of biological characteristics,detection techniques,and clinical application,so as to provide a basis for clinical diagnosis and treatment.
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