Abstract

Catalyst has a noteworthy role in chemical processes in both industrial and scientific fields. Use of catalyst can helps to serve less energy, time and money. As a result, chemical process became more eco-friendly and economical. Nanocatalysts are an important branch in this issue. Multicomponent reactions (MCRs) are one of the most effective strategies in the field of green chemistry; witch is the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture, and application of chemical products. Therefore, by application of nanocatalysts in MCRs, chemical synthesis can approach aims of green and sustainable chemistry. As it is mentioned nanocatalyst, are important field and have many advantages in recent years. Magnetic nanocatalysts are a subdivision of catalyst and beneficial strategy in green chemistry. Biocatalysts are another one either. Meet of these two branches results a new, efficient and green nanocatalyst. Chitosan is a biopolymer and it is used in many organic syntheses as catalyst, supporting this with a magnetic nanocatalystmodified this biocatalyst and enhance its properties, also leads to another efficient and green catalyst.

Highlights

  • Catalyst has a noteworthy role in chemical processes in both industrial and scientific fields

  • The Strecker reaction between an aldehyde, an amine and hydrogen cyanide is widely regarded as the first multicomponent reactions (MCRs) in organic chemistry and it is the oldest known synthesis of α-amino nitriles that for the first time was reported by Strecker in 18505

  • In continuation of our interest in the application of new catalysts in organic synthesis via MCRs11, efficient and selective syntheses of ߙ-amino nitrile derivatives were carried out using different aromatic aldehydes with amines and trimethylsilyl cyanides in the presence of a catalytic amount of magnetically recoverable chitosan supported magnetic nanoparticles in ethanol at ambient temperature in high yields (Scheme 1)

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Summary

Introduction

Catalyst has a noteworthy role in chemical processes in both industrial and scientific fields. The Strecker reaction between an aldehyde, an amine and hydrogen cyanide is widely regarded as the first multicomponent reactions (MCRs) in organic chemistry and it is the oldest known synthesis of α-amino nitriles that for the first time was reported by Strecker in 18505 This reaction is one of the most direct and efficient methods for the synthesis of α-amino nitriles. In continuation of our interest in the application of new catalysts in organic synthesis via MCRs11, efficient and selective syntheses of ߙ-amino nitrile derivatives were carried out using different aromatic aldehydes with amines and trimethylsilyl cyanides in the presence of a catalytic amount of magnetically recoverable chitosan supported magnetic nanoparticles in ethanol at ambient temperature in high yields (Scheme 1). Further purification was followed by crystallization from ethanol to give pure product as pale yellow crystals

Results and discussion
H Phenyl 4c
Conclusions

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