Abstract
AbstractIn this study, we proposed carbonyl iron powder (CIP) as a novel mediator for arterial embolization hyperthermia (AEH). In vitro cytotoxicity study with cultured L929 cells was carried out to test the biocompatibility of the CIP. Effect of alternative magnetic field (AMF) on the temperature rise of CIP was performed by exposing the CIP/Lipiodol suspensions under AMF with different field strength. In vivo heating curve of the hepatic artery after transcatheter arterial embolization (TAE) was also conducted by applying New Zealand half lop rabbits as animal model. Cytotoxicity study demonstrated that CIP showed good biocompatibility. Heating curves, both in vitro and in vivo, revealed that CIP possessed ideal property of inductive heating characteristics under AMF. Our findings suggest that CIP is a very promising mediator candidature of AEH for clinical application.KeywordsMagnetic Inductive HyperthermiaArterial Embolization HyperthermiaCarbonyl Iron PowderHeatingCancer Targeted Treatment
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