Abstract
Digital signal processing is gaining popularity in gene classification and prediction. Spectral content of gene is estimated using Blackman---Tukey (BT) method for identification of Homo sapiens cancer genes. A data reduction method; principal component analysis (PCA) is used prior to Blackman---Tukey method (PC-BT) for better identification of genes. Selection of proper model order is prime important in PCA method for considering the number of principal components (PCs) and the performance of the method depends on optimal selection of PCs. Cumulative percent variance and scree test residual percent variance are used as measurement metric for selection of PCs. Quality factor is used to judge the performance of the estimators. Simulation results show the clarity of spectrum plot in PC-BT method is 200 % higher than BT method. The spectral peaks observed in cancer genes are used to screen out cancer genes from healthy genes. The methods are successfully tested on breast, prostate and colon Homo sapiens. Healthy and cancer Homo sapiens genes are downloaded from Cancer Genome Anatomy Project (CGAP) site and National Centre for Biotechnology Information (NCBI) site.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
