Abstract
The objective of this study was to optimize nanostructured lipid carriers (NLC) for clobetasol propionate using Box-Behnken design (BBD). The formulation was developed by incorporating oleic acid, compritol ATO-888, and tween 80, using the hot homogenization method. The BBD, which employed a 3-level, 3-factor design, investigated the impact of lipid ratio, surfactant concentration, and sonication time on particle size, polydispersity index, and entrapment efficiency (EE). By analyzing the models through ANOVA and diagnostic plots, the optimized formulation composition was selected using the desirability function. The results indicated that a drug-lipid ratio of 1:7.5 was optimal for all formulations. The spherical-shaped nanostructured lipid carriers had a size of 168.3 ± 0.367 μm, a polydispersity index of 0.248183 ± 0.2847, an EE of 85.4 ± 0.384%, and a desirability value of 0.979. Overall, the use of BBD proved to be a valuable tool in developing optimized NLC with desired properties.
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