Abstract
Application of Boolean Algebra (Mathematical Logic) for Definition of Acute Leukemias
Highlights
Acute leukemias are malignant tumors derived from normal progenitor cells in the bone marrow
We have described Boolean algebra as a mathematical tool for the definition of complicated diseases such as acute leukemias
Theoretical chemistry and theoretical biology were established as academic disciplines in the 20th century, theoretical medicine remains to be developed
Summary
Acute leukemias are malignant tumors derived from normal progenitor cells in the bone marrow These progenitor cells are called blasts, which under normal circumstances differentiate into leucocytes, erythrocytes, and thrombocytes. Until well over the middle of the 20th century acute leukemias were diagnosed with the microscope In many cases, this method posed challenges in discriminating leukemic from normal blasts and ALL from AML. The normal blast proportion in bone marrow is below 5 % This method had the disadvantage that the disease was advanced at diagnosis. The diagnosis of acute leukemias significantly improved with the development of immunologic and molecular methods Both methods permitted the detection of the disease at an earlier stage called measurable residual disease (MRD) and the discrimination between leukemic and normal blasts. A detailed overview on recurrent genetic abnormalities in ALL was published by Gerhard Zugmaier [11]
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